The second game in the Fallout series, and the sequel to Fallout 1.
The game takes place in 2241, 80 years after the events of Fallout 1 and 164 years after the Great War. It follows the Chosen One, a descendant of the Vault Dweller from Fallout 1, and their quest to save their tribe by finding the Garden of Eden Creation Kit.
This tag implicates fallout_(series) (learn more).