Is it yuri if they're both women, but one of them is playing a male character? Semi-serious question.
(If you don't know: Gigi forgot that the brief for ENigmatic Recollection's characters was "yourself, but with amnesia" and created a male persona for herself in the game. In practice, it was left undetermined whether Sir Gonathan G actually was a man who happened to look like Gigi, or Gigi herself, so profoundly disoriented that she didn't notice she wasn't a man.)