You Look Lonely, also known as Sad Officer K, refers to a scene from 2017 film Blade Runner 2049 in which the main protagonist K, played by Ryan Gosling, silently watches a giant holographic advertisement after having been badly injured. Following the film's trailer and release, the scene circulated as an exploitable, with K and Joi usually replaced with other characters. As the meme developed, K's face bathed in purple light became widely used as an image macro expressing sadness and despair.
Source: You Look Lonely | Know Your Meme
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