Yosuga no Sora is a bishoujo eroge game by Sphere, first released in 2008. Known as "Yosusora" for short. Illustrated by Hashimoto Takashi and Suzuhira Hiro. The franchise also includes a 2010 manga and a 2010 softcore TV anime.
(In)famous for setting up the precedent of the siscon-brocon anime trope that later became something of a norm (though much toned down in mainstream media compared to the series' outright incestous themes).