Three separate memes with similar format of a character saying the word "Pathetic" while looking down in disgust:

• The first originated from the second episode of The Simpsons featuring Principal Skinner.
• The second version features Souryuu Asuka Langley from Neon Genesis Evangelion.
• The third one is based on a selfie of Jenna Lynn Meowri taken from below.

Origins

Skinner version

Asuka version

Meowri version

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