A meme inspired by a page from the hentai doujin Tiny Boobs Giant Tits History by Shiden Akira, in which a girl wearing a Mega Milk shirt fondles her breasts while making a crazed expression.
The plot of the doujin revolves around a brother who previously teased his sister for her flat chest, only for her to turn the tables when she grows a knockout pair of breasts.
Page 3 of an English scanlation by the translation group Rhapfan of the doujin was spammed on 4chan across multiple imageboards around 2008, most prominently in /v/, in an apparent attempt to force a meme with the line "Shut the fuck up you titty monster.".