In the game Rain World, Iterators are sapient artificial intelligences running on semi-biological supercomputers of colossal scale (large enough to build cities on top of). Most often an Iterator is depicted through its "puppet": a humanoid robot connected to the hardware via an umbilical cable. Each Iterator's puppet has a characteristic design which includes skin color, a unique forehead mark. and various styles of robot ears.
Five Iterators play significant roles in the events of the game:
Consistently, Moon and Straw take female pronouns (and Moon self-identifies as "Big Sis Moon"), Five Pebbles and NSH take male pronouns, while Seven Red Suns takes neuter "they". The basis for this is unknown.