Is it yuri if they're both women, but one of them is playing a male character? Semi-serious question.
(If you don't know: Gigi forgot that the brief for ENigmatic Recollection's characters was "yourself, but with amnesia" and created a male persona for herself in the game. In practice, it was left undetermined whether Sir Gonathan G actually was a man who happened to look like Gigi, or Gigi herself, so profoundly disoriented that she didn't notice she wasn't a man.)
Is it yuri if they're both women, but one of them is playing a male character? Semi-serious question.
(If you don't know: Gigi forgot that the brief for ENigmatic Recollection's characters was "yourself, but with amnesia" and created a male persona for herself in the game. In practice, it was left undetermined whether Sir Gonathan G actually was a man who happened to look like Gigi, or Gigi herself, so profoundly disoriented that she didn't notice she wasn't a man.)
It's tag what you see, not what you know, and while Gonathan G identifies as a man that's still just Gigi, who is definitely a girl. I.e. If this was Romeo and Juliette with Gigi and Romeo and Juliette as Ame, it'll still be yuri even if Gigi "Romeo" acts and is identified as a male character.
Gregor, Sinclair, Yi Sang, Ishmael and Heathcliff: "I must confront my past, and in doing so, realize the potential of my future. My trauma is my strength."
In a Pokémon fanfic I've read called Ashes of the Past, Ash's Squirtle is actually a huge Tengen Toppa Gurren Lagann fan. Check it out, if only for Kamina Squirtle.
Given that the uncertainty of Mizuki's gender and their inability to come out, I think it still reflects a lot of trans and non-binary people in unaccepting society and environment (I am not trans or non-binary, just my thought).