Given that the uncertainty of Mizuki's gender and their inability to come out, I think it still reflects a lot of trans and non-binary people in unaccepting society and environment (I am not trans or non-binary, just my thought).
as others have pointed out: there's some interesting implications to the fact that Kikyou is clearly worried about Kasuza eating the cake + Serika eating pre-packaged food instead of the cake... did Kayoko lace it with something (or, at the very least, do they think she did)?
I'm also a little unsure of Aya's last line. It looks like ใใใฐใฃใใฏใญใผ or ใใใฑใฃใใฏใญใผ, but I'm not making full sense of either.
Thanks. I was too unfocused to work out that handwriting. I still need to defer translating the small writing in panel 3 until later, but I figured I could fix this line for now.
Almost forgot: Reader-added tags include "Japanese sake," "Bottomless swamp," and "Welcome...to the rabbit hole." ("Swamp" is the Japanese idiomatic equivalent of "rabbit hole" for something you could metaphorically fall into endlessly, and it still kind of works in English. It felt more natural to me to keep it as "swamp" for the second tag.)
reminds me of the story of "Quo Vatus" Peter was fleeing from Rome and saw Jesus walking back toward Rome, Peter Asked "where are you going" (Quo Vatus) and Jesus said "to Rome to be crucified again", Peter would return to Rome and be crucified, his final request being that they not do it the same way they did it to Jesus, so they put him on the cross upsidedown.